Diet and Gut Microbiota, Don’t Let Them Break Your Heart!

Authors

  • Gaston Cluzel

DOI:

https://doi.org/10.33178/boolean.2022.1.27

Keywords:

Obesity, Gut Microbiota, Diet, Cardiovascular Disease, Immune System

Abstract

As rising obesity rates threaten to overwhelm healthcare services, physicians still lack efficacious therapies to halt the cardiovascular complications of the disease. The gut microbiota – a whole community of microorganisms that resides in our intestine – has recently emerged as major player in human health. Crucially, the gut microbes are extremely dependant on our dietary habits, and promote both health and disease. In obese patients, the gut microbiota is found to be profoundly altered, which is believed to promote disease complications including cardiovascular disorders. On the other hand, the preservation of a healthy gut microbiota has protective effects against obesity-related complications, which can be promoted by certain diets. Consequently, understanding the relationship between diet, the gut microbiota, and our body could help physicians to develop new strategies for preventing cardiac diseases in obese patients.

References

Fernanda Cristofori, Vanessa Nadia Dargenio, Costantino Dargenio, Vito Leonardo Miniello, Michele Barone, and Ruggiero Francavilla. Anti-inflammatory and immunomodulatory effects of probiotics in gut inflammation: a door to the body. Frontiers in immunology, 12:178, 2021.

Cindy D Davis. The gut microbiome and its role in obesity. Nutrition today, 51(4):167, 2016.

Ellulu MS, Patimah I, Khaza’ai H, Rahmat A, Abed Y. Obesity & inflammation: The linking mechanism & the complications. Arch Med Sci 13: 851–863, 2017. doi: 10.5114/aoms.2016.58928.

Hansson GK, Robertson AKL, Söderberg-Nauclér C. Inflammation and atherosclerosis. Annu. Rev. Pathol. 1 Annual Reviews Inc.: 297–329, 2006.

Inoue Y, Qin B, Poti J, Sokol R, Gordon-Larsen P. Epidemiology of Obesity in Adults: Latest Trends. Curr. Obes. Rep. 7 NLM (Medline): 276–288, 2018.

McRae MP. Dietary Fiber Is Beneficial for the Prevention of Cardiovascular Disease: An Umbrella Review of Meta-analyses. J Chiropr Med 16: 289–299, 2017. doi: 10.1016/j.jcm.2017.05.005.

Oniszczuk A, Oniszczuk T, Gancarz M, Szyma?ska J. Role of gut microbiota, probiotics and prebiotics in the cardiovascular diseases. Molecules 26 MDPI AG: 2021.

C Riehle and J Bauersachs. Key inflammatory mechanisms underlying heart failure. Herz, 44(2):96–106, 2019.

Theresa V Rohm, Regula Fuchs, Rahel L M¨uller, Lena Keller, Zora Baumann, Angela JT Bosch, Romano Schneider, Danny Labes, Igor Langer, Julia B Pilz, et al. Obesity in humans is characterized by gut inflammation as shown by pro-inflammatory intestinal macrophage accumulation. Frontiers in immunology, 12:668654, 2021.

Downloads

Published

2022-12-09

Issue

Section

Articles